IE9 won't allow me to run or open downloads

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Hello, I am having a problem with IE9.  I am running Windows 7 Pro with all the updates and patches.  If I go to adobe.com and try to download Flash, IE9 will prompt me to Run, Save, Cancel.  If I select Run nothing happens after that.  It is not just adobe.com that this happens but any site where I wish to run the program.

This also occurs when I want to open a document upon download.  If I am downloading a PDF file and I am prompted for Open, Save, Cancel, if I select Open nothing happens after that.

I have run IE9 in no add-ons and the same things happens.

Any thoughts?

Thanks!